Have you patched your game with patches?
If not where did you get your PES 2010? If you downloaded it, I suggest finding a new installation file, if you bought the game there could be a chance there is a corrupted file on it. Just go swap your game around then and explain your issue.
If all modes are working on your PC then I would not think it is your PC giving problems.. Try this, Just go to edit and try to create a player and see if your game crashes then.