I play the 4-1-2-1-2 with my PL squad (no exploiting through passes for me though!), and a 4-5-1 (2 DM, 1 CAM, RM and LM) with my La Liga team. Ultimately (pun half intended), it's whatever works well for you with the players you have. Some days I struggle with 4-5-1, some days I play lovely...