Hmm a 4-1-2-1-2 is my formation which is quite effective in my ML game..
4 defender 2 CB 2 SB, 1 CMF 2 LMF/RMF 1AMF 2 striker, try to search for strong midfieder which can bring the ball up to your striker.. Striker dont have to be very good as long as it have good shot ACC/ shot TECH to...