Another tip from me concern big money purchases you make:
We all want those Agueros, Benzemas, Zarates, Gourcuffs and who not on our team, but the CPU makes us pay big time more often than not.
So once you are tabled an offer from the CPU, consider your current bankroll, your team's salary, the additional salary that the new player will cost and the transfer fee, or otherwise you may be confronted with a really uncomfortable situation some time in the near future.
Example:
I desperately wanted Benzema on my team. I approached him numerous times, that is: every time my approach was turned down I would pursue him again, I did that since my very first day of the ML.
Now, just over midway through the second season I finally got an offer from Real Madrid, asking for 107€ million and a 15€ million salary. I suppose that I could have gotten that down to about 85-90€ and 12€ million. At first I was uber happy that I could finally get him and was well happy with my bankroll of about 185€ million. But I then realised, that paying a transfer fee of about 90€ million and a team salary that would total about just over 100€ million including Benzema, would leave me with a negative or close to zero bankroll in September after I would have paid the team's salary, staff etc. Which would have meant that I would have needed to quit playing after the following season.
So I ended up turning the offer down.
Obviously, if you have players to sell which can get you the money back, that's a slightly different scenario, but I would still advise you to be careful with those transfers.