What I do is, edit the Konami cup to Copa America with 16 teams, with the world cup rules, then I add all the North and Central America teams. I did the same thing when I started my World Cup qualifiers. I started Konami League with 16 teams and so far it's really fun. Top 7 go to the world cup, 8th place play two games play-off with Asia and and 9th place with Oceania ( New Zealand, always).
African Cup is better because you don't have to add any team from another region making it more realistic, but at the end it's all fantasy and the format I use for American Cup and Qualifiers works for me.