@roryK... Macfee is the worst anti virus to use, its cheap but it hogs all your system resources. Go for Kaspersky or AVG, AVG btw is free.
Like I have said in my posts, I have no idea what I did to get rid of that error... I formatted once, installed all drivers, then installed PES and I got the error! Then.... I reformatted!! installed all the same drivers, then installed PES and it worked??????????
I also contacted konami, the guy on the phone ask me to run "DXDIAG" then send the information over to konami, which I did do... After waiting a few days I got bored, so I attempted to try and fix the problem myself. Just after I got it working, konami emailed me back!! lol... Asking for me to send the DXDIAG information, which I sent already. So I can't be bothered any more as I have it working.
So if you want, try the above... Format, JUST install your latest drivers nothing else. Then try PES.